Injection sites
OZEMPIC® is to be injected subcutaneously in the abdomen, in the thigh or in the upper arm. The injection site can be changed without dose adjustment.[2]Section 4.4, page 6
Ozempic Injection & Storage (Canada)
semaglutideNovo Nordisk
OZEMPIC® is indicated for the once-weekly treatment of adult patients with type 2 diabetes to improve glycemic control.
About this page. This page summarizes injection technique and storage instructions published by Health Canada in the product monograph for Ozempic. It is for informational purposes only and is not a substitute for advice from your prescriber or pharmacist. Always follow the instructions provided to you by your healthcare provider. Read our full medical disclaimer →
Injection
Site rotation and needle removal
Rotate injection sites with each dose. Do not use the same site for each injection. When using OZEMPIC® with insulin, it is acceptable to inject in the same body region but the injections should not be adjacent to each other. Always remove the injection needle immediately after each injection and store OZEMPIC® without a needle attached. This may prevent blocked needles, contamination, infection, leakage of solution and inaccurate dosing.[2]Section 4.4, page 6
What to inspect before injecting
Inspect OZEMPIC® visually before use. It should appear clear and colourless. Do not use OZEMPIC® if particulate matter and colouration is seen. OZEMPIC® should not be used if it does not appear clear and colourless.[2]Section 4.4, page 6
Route restrictions and insulin co-administration
OZEMPIC® should not be administered intravenously or intramuscularly. When using OZEMPIC® with insulin, instruct patients to administer as separate injections and to never mix the products.[2]Section 4.4, page 6
Single-patient use and compatible needles
Each OZEMPIC® pen is for use by a single patient. An OZEMPIC® pen must never be shared between patients, even if the needle is changed. OZEMPIC® can be administered with needles up to a length of 8 mm. The pen is designed to be used with NovoFine® disposable needles. Substances added to OZEMPIC® may cause degradation of semaglutide. OZEMPIC® must not be mixed with other medicinal products, e.g. infusion fluids.[1]Section 12, page 22
Storage
Refrigerated storage before first use
Prior to first use, store OZEMPIC® refrigerated at 2°C to 8°C until the expiration date. Keep away from the cooling element. Do not freeze OZEMPIC® and do not use OZEMPIC® if it has been frozen.[3]Section 11, page 22
In-use storage after first use
After first use, OZEMPIC® may be stored at room temperature below 30°C for up to 8 weeks, or kept refrigerated at 2°C to 8°C. Keep the pen cap on when OZEMPIC® is not in use in order to protect from light.[3]Section 11, page 22
Light and heat protection
Protect from excessive heat and light. Keep the pen cap on when OZEMPIC® is not in use in order to protect from light.[3]Section 11, page 22
Disposal
Needle disposal after each injection
The patient should be advised to discard the injection needle after each injection in accordance with local requirements.[1]Section 12, page 22
Talk to your pharmacist or prescriber
Injection technique and storage requirements must be understood in the context of your specific device and medication. Discuss any questions about administration or storage with your prescriber or pharmacist. Use our pharmacy comparison tool to find and connect with a Canadian pharmacy that carries Ozempic.
Sources
Last reviewed May 14, 2026 against the Health Canada Product Monograph dated April 14, 2026. View monograph →