ZEPBOUND (tirzepatide injection) is indicated for once-weekly administration for chronic weight management, including weight loss and weight maintenance, as an adjunct to a reduced-calorie diet and increased physical activity, in adults with obesity (BMI ≥ 30 kg/m²) or overweight (BMI ≥ 27 kg/m²) with at least one weight-related comorbid condition.
About this page. This page summarizes injection technique and storage instructions published by Health Canada in the product monograph for Zepbound. It is for informational purposes only and is not a substitute for advice from your prescriber or pharmacist. Always follow the instructions provided to you by your healthcare provider. Read our full medical disclaimer →
Prior to initiation of ZEPBOUND, train patients and caregivers on proper injection technique. Advise the patient to carefully read the Instructions for Use included with the Patient Medication Information, and to watch the instructional videos, before administering the medicinal product.[2]Section 4.4, page 5
Inject ZEPBOUND subcutaneously in the abdomen, thigh, or upper arm. Rotate injection sites with each dose.[3]Section 4.4, page 6
Inspect ZEPBOUND visually before use. It should appear clear and colorless to slightly yellow. Do not use ZEPBOUND if particulate matter or discoloration is seen. ZEPBOUND should not be used if the solution does not appear clear, free of particles, and colourless to slightly yellow. ZEPBOUND should not be used if the pen is damaged. If the KwikPen is dropped on a hard surface, it should not be used.[2]Section 4.4, page 5
ZEPBOUND should not be administered intramuscularly or intravenously.[3]Section 4.4, page 6
Each ZEPBOUND multi-dose KwikPen delivers four doses. Patients using ZEPBOUND go through one pen per month as each pen delivers 4 doses of tirzepatide.[4]Section 12, page 21
Store ZEPBOUND in a refrigerator at 2°C to 8°C up to the expiration date. Do not use ZEPBOUND beyond the expiration date. Do not freeze ZEPBOUND. Do not use ZEPBOUND if frozen. Protect ZEPBOUND from light.[1]Section 11, page 20
If needed, each multi-dose pen can be stored unrefrigerated at temperatures not to exceed 30°C for up to 30 days.[1]Section 11, page 20
The ZEPBOUND multi-dose KwikPen contains 4 doses. The pen must be discarded in a puncture-resistant container, or in accordance with local requirements after the four weekly doses of ZEPBOUND have been used.[1]Section 11, page 20
Injection technique and storage requirements must be understood in the context of your specific device and medication. Discuss any questions about administration or storage with your prescriber or pharmacist. Use our pharmacy comparison tool to find and connect with a Canadian pharmacy that carries Zepbound.
Last reviewed May 14, 2026 against the Health Canada Product Monograph dated April 2, 2026. View monograph →