Zepbound Dosing Guide (Canada)
ZEPBOUND (tirzepatide injection) is indicated for once-weekly administration for chronic weight management, including weight loss and weight maintenance, as an adjunct to a reduced-calorie diet and increased physical activity, in adults with obesity (BMI ≥ 30 kg/m²) or overweight (BMI ≥ 27 kg/m²) with at least one weight-related comorbid condition.
About this page. This page summarizes dosing information published by Health Canada in the product monograph for Zepbound. It is for informational purposes only and is not a substitute for advice from your prescriber or pharmacist. Always follow the dosing instructions provided to you by your healthcare provider. Read our full medical disclaimer →
Titration Schedule
Weeks 1–4
2.5 mg
once weekly
[1]Section 4.2, page 5Initiation dose.
Weeks 5–8
5 mg
once weekly
[1]Section 4.2, page 5Also a recommended maintenance dose per Section 4.2.
Weeks 9–12
7.5 mg
once weekly
[1]Section 4.2, page 5Escalation step; remain ≥ 4 weeks on current dose before increasing.
Weeks 13–16
10 mg
once weekly
[1]Section 4.2, page 5Also a recommended maintenance dose per Section 4.2.
Weeks 17–20
12.5 mg
once weekly
[1]Section 4.2, page 5Escalation step.
Week 21+
15 mg
once weekly
Maximum recommended maintenance dose.
If you miss a dose
If within 4 days
If a dose is missed, administer ZEPBOUND as soon as possible within 4 days (96 hours) after the missed dose. Resume the regular once-weekly dosing schedule.
If outside 4 days
If more than 4 days have passed, skip the missed dose and administer the next dose on the regularly scheduled day. Resume the regular once-weekly dosing schedule.
Talk to your pharmacist or prescriber
Dosing decisions — including when to adjust or maintain your dose — must be made with your prescriber or pharmacist. Use our pharmacy comparison tool to find and connect with a Canadian pharmacy that carries Zepbound.
Sources
Last reviewed May 14, 2026 against the Health Canada Product Monograph dated April 2, 2026. View monograph →